\tikzsetnextfilename{Frequenzkontrolle-des-VHF}

    \begin{tikzpicture}[node distance=2cm]
    
    \node (about) [about, text width=3cm, ] {\textbf{VHF}};

    \node (comorbidity0) [comorbidity, below of=about, xshift=-8.1cm, yshift=-2.5cm, text width=2.5cm] {\textbf{Komorbi-ditäten}};

    \node (comorbidity1) [comorbidity, right of=comorbidity0, xshift=1.25cm, text width=2.5cm] {keine andere kardiovaskuläre Krankheit};
    \node (comorbidity2) [comorbidity, right of=comorbidity1, xshift=1.25cm, text width=2.5cm] {Hypertension oder dias\-to\-lische Herzinsuffizienz};
    \node (comorbidity3) [comorbidity, right of=comorbidity2, xshift=1.25cm, text width=2.5cm] {Dysfunktion des linken Ventrikels oder Herzinfarkt};
    \node (comorbidity4) [comorbidity, right of=comorbidity3, xshift=1.25cm, text width=2.5cm] {COPD};

    \draw [arrow] (about) -- (comorbidity1);
    \draw [arrow] (about) -- (comorbidity2);
    \draw [arrow] (about) -- (comorbidity3);
    \draw [arrow] (about) -- (comorbidity4);

    \node (therapy0) [therapy, below of=comorbidity0, yshift=-1cm, text width=2.5cm] {\textbf{me\-di\-ka\-men\-tö\-se Therapie}};

    \node (therapy1) [therapy, below of=comorbidity1, yshift=-1cm, text width=2.5cm] {$\beta$-Blocker, Diltiazem, Verapamil};
    \node (therapy2) [therapy, below of=comorbidity2, yshift=-1cm, text width=2.5cm] {$\beta$-Blocker, Diltiazem, Verapamil};
    \node (therapy3) [therapy, below of=comorbidity3, yshift=-1cm, text width=2.5cm] {$\beta$-Blocker, Digitoxin};
    \node (therapy4) [therapy, below of=comorbidity4, yshift=-1cm, text width=2.5cm] {$\beta$-Blocker, Diltiazem, Verapamil};

    \draw [arrow] (comorbidity1) -- (therapy1);
    \draw [arrow] (comorbidity2) -- (therapy2);
    \draw [arrow] (comorbidity3) -- (therapy3);
    \draw [arrow] (comorbidity4) -- (therapy4);

    %\node (therapy4) [therapy, below of=therapy2, yshift=-1cm, text width=2.5cm] {Amiodaron};

    \draw [decoration={brace, mirror, raise=1.25cm, amplitude=0.5cm}, decorate] ([xshift=-1mm]therapy1.west) -- node [below=2cm, therapy] {Amiodaron} ([xshift=1mm]therapy3.east);

    \draw ([yshift=4cm, xshift=1.62cm]comorbidity0.north) -- ([yshift=-1.5cm, xshift=1.62cm]therapy0.south);
    
    \end{tikzpicture}